Antiemetics in hematopoietic cell transplantation:

Antiemetics play a key role in hematopoietic cell transplantation (HCT). High-dose chemotherapy and total body irradiation (TBI) have high emetogenic potential, vomiting nausea during conditioning regimen thereafter impair oral intake, which can lead to weight loss, hyperglycemia due parenteral nutrition, infectious disease, increased transplant-related mortality. We searched for randomized trials on antiemetics HCT. Triplet prophylaxis with 5-HT antagonist, an NK-1 dexamethasone is common practice transplantation. Prophylaxis usually given the sometimes up few days later. antagonist usage supported by trials. Olanzapine reduces nauseas, based trial. Although recommended ASCO guideline, use of should be considered controversial higher incidence adverse events this medication study possible risk infections, therefore used caution as antiemetic Metoclopramide, diphenhydramine, lorazepam are other drugs that also activity, been HCT, selected cases.